Skip to main content

Treatment of Febrile illness with artemisinin combination therapy: prevalence and predictors in five African household surveys



To evaluate the determinants of compliance with national policies recommending Artemisinin Combination Therapy (ACT) for the treatment of uncomplicated malaria in the community.


We used data from Gambia, Ghana, Kenya, Nigeria, and Uganda national household surveys that were conducted with a standardized World Health Organization (WHO) methodology to measure access to and use of medicines. We analyzed all episodes of acute fever reported in the five surveys. We used logistic regression models accounting for the clustered design of the surveys to identify determinants of seeking care in public healthcare facilities, of being treated with antimalarials, and of receiving ACT.


Overall, 92% of individuals with a febrile episode sought care outside the home, 96% received medicines, 67% were treated with antimalarials, and 16% received ACT. The choice of provider was influenced by perceptions about medicines availability and affordability. In addition, seeking care in a public healthcare facility was the single most important predictor of treatment with ACT [odds ratio (OR): 4.64, 95% confidence intervals (CI): 2.98–7.22, P < 0.001]. Children under 5 years old were more likely than adults to be treated with antimalarials [OR: 1.28, CI: 0.91–1.79, not significant (NS)] but less likely to receive ACT (OR: 0.80, CI: 0.57–1.13, NS).


Our results confirm the high prevalence of presumptive antimalarial treatment for acute fever, especially in public healthcare facilities where poor people seek care. They show that perceptions about access to medicines shape behaviors by directing patients and caregivers to sources of care where they believe medicines are accessible. The success of national policies recommending ACT for the treatment of uncomplicated malaria depends not only on restricting ACT to confirmed malaria cases, but also on ensuring that ACT is available and affordable for those who need it.


Artemisinin-Combination Therapy (ACT) is considered the most effective pharmaceutical intervention to control malaria, in conjunction with long-lasting insecticidal nets (LLIN), indoor residual spraying (IRS) and intermittent presumptive treatment (IPT) with Sulfadoxine/Pyrimethamine (SP) during pregnancy [1-5]. In recent years, national policies have endorsed first-line treatment with ACT for uncomplicated malaria in countries at high risk of malaria. Implementation of such policies presents considerable challenges on the supply side to ensure adequate funding through international subsidies, sufficient manufacturing of co-blistered combinations in line with internationally recommended standards, and uninterrupted distribution [6,7]. On the demand side, deep-rooted treatment behaviors and high ACT retail prices have slowed the adoption of the policy by healthcare providers and patients alike [8,9].

ACTWatch household surveys conducted at the start of the Affordable Medicines Facility-malaria (AMFm) initiative found that less than half of children under 5 years old with fever received ACT [10-13]. Little evidence exists about the attitudes and perceptions of patients and caregivers regarding national recommendations to switch from well-established practices to new treatment paradigms. Yet, a better understanding of the factors slowing the adoption of ACT is needed [14]. The objectives of this study were to describe the early compliance with national policies recommending ACT as first-line therapy for suspected malaria and to identify predictors of ACT use in communities at high risk of malaria. To investigate the extent of ACT utilization by households and the determinants of ACT use, we analyzed existing data from household surveys that were conducted with a standard methodology developed by the World Health Organization (WHO) to measure medicines access and use in low- and middle-income countries.


Survey methodology, data collection and management

The WHO methodology to measure medicines access and use with standardized rapid cluster sample household surveys has been previously described [15]. This study includes five surveys in countries at high risk of malaria that were conducted with the original WHO methodology (The Gambia, Nigeria) or the revised Medicines Transparency Alliance (MeTA) methodology (Ghana, Kenya, and Uganda). Data collection took place in August 2007 (Nigeria), October 2007 (The Gambia), May-June 2008 (Ghana), July-August 2008 (Uganda) and September-October 2008 (Kenya). The open source software EpiData Entry v.2.0 (The EpiData Association, Odense, Denmark) was used for data entry. All medicines names were entered as collected and their equivalent generic nomenclature was coded with a Microsoft Exceltm tool based on the WHO 15th Model Essential Medicines List [16]. All medicines coded 6.531 “antimalarial” are included in this analysis.


We received anonymized country survey datasets from local teams after obtaining Harvard Pilgrim Health Care Institutional Review Board approval to conduct the study. We imported them into StataSE V.11.2 (StataCorp, College Station, Texas). All analyses used the Survey commands of Stata to account for the clustered sample design and to adjust for the disproportioned allocation of sample clusters between the capital (or most densely populated) region and other areas of a country. In combined analyses, we weighted each country survey population equally rather than proportional to country population size in order to prevent multi-country results from being dominated by the Nigeria results. At the time of data collection, the WHO/MeTA surveys did not collect information on malaria diagnostic tests. In the absence of confirmed diagnosis with a parasite-based test, clinical suspicion of malaria and presumptive treatment are based on the presence of fever [17,18]. Therefore we included in our analysis all individuals with acute symptoms recorded under the group of symptoms “fever, headache, hot body”.

We hypothesized that episodes of acute fever would be treated differently in the public and private sectors because changes in national antimalarial policies at the time of the surveys targeted primarily public healthcare facilities. We used the Stata survey multivariate logistic regression commands to identify predictors of the decision to seek care in a public healthcare facility rather than in the private sector and of subsequent use of antimalarials and ACT in presence of acute fever.

Potential predictor variables included in the model were health services-related (sources of care accessed during acute fever), household-related (location, socio-economic status, proximity of healthcare facilities, respondent education, respondent opinions on medicines access) and patient-related (patient gender, age under 5 years old, associated symptoms, perceived severity of fever). Socio-economic satus of households was assessed from the self-reported monthly expenditure quintile; expenditure quintile boundaries were calculated from the most recent national household economic survey adjusted for household size. Households in the lowest quintile were considered poor; households in the other quintiles were considered non-poor.


Characteristics of surveyed households

The characteristics of all 5261 surveyed households, including prevalence of acute illness, have been previously described [15]. Table 1 presents the differences observed between the households surveyed in capitals and in other parts of the countries, and between poor and non-poor households. In capital areas, a lower proportion of households was poor (estimated proportion: 10.8% vs. 35.6%, p < 0.001), situated far from public healthcare facilities (9.1% vs. 15.3%, p < 0.05), and far from private healthcare providers (16.3% vs. 35.0%, p < 0.001) or medicines retail outlets (7.5% vs.15.3%, p < 0.05). Higher proportions of respondents living in capital areas were female (66.5% vs. 48.3%, p < 0.001), between 25–50 years old (76.9% vs. 66.5%, p < 0.001), with education beyond high school (26.3% vs.18.3%, p < 0.05), and of the opinion that medicines are affordable (53.4% vs. 42.2%, p < 0.05). Poor households shared many of the attributes of households outside capital areas. In addition, the proportion of households stocking medicines at home was lower if households were poor (39.4% vs. 52.6%, p < 0.001), even though a higher proportion of poor respondents reported an acute illness in the preceding 2 weeks (55.4% vs. 48.7%, p = 0.01).

Table 1 Demographic and socio-economic characteristics of surveyed households

Of the 2000 individuals with a recent febrile episode, 91.8% sought care outside the home, 96.0% took medicines, 67.0% received antimalarials, and 16.2% received ACT. Several characteristics differed between sick individuals from households in capital vs. non-capital areas. In capital areas, lower proportions of respondents reported a severe fever (12.6% vs. 21.8%, p < 0.001), were treated in a public healthcare facility (43.6% vs. 53.6%, p < 0.05), received ACT (9.0% vs. 18.5%, p < 0.05) or antibiotics (20.7% vs. 34.8%, p < 0.005). (Table 2) The proportion of sick individuals from poor households who sought care outside the home was lower (88.3% vs. 93.4, p < 0.005), the proportion traveling more than one hour to receive care was higher (23.3% vs. 13.1%, p < 0.001), and the proportion receiving analgesics or NSAIDS was lower (65.2% vs. 70.6%, p < 0.05) than in the group from non-poor households.

Table 2 Demographic characteristics, severity and actions taken for episodes of acute fever in the two weeks preceding the survey according to socio-economic status and geographic location

Use of antimalarials and ACTs to treat acute fever

The profile of antimalarials used to treat acute fever varied greatly across surveys, and the proportion of fevers treated with ACT varied from none in Gambia to 26.6% in Ghana. In the Gambia survey, chloroquine, SP, and quinine were the only antimalarials reported to treat fever, while a variety of different antimalarial medications were documented in the four other surveys. (Table 3) When ACT was used, the choice of artemisinin combination usually appeared to be consistent with national policies in effect at the time of the surveys: i.e., artesunate + amodiaquine (AS + AQ) in Ghana, artemether + lumefantrine in Kenya, Nigeria, and Uganda. The proportion of individuals with acute fever who obtained all the medicines prescribed or recommended in a public healthcare facility was consistently higher in the group of patients who received ACT (Figure 1).

Table 3 Use of antimalarials among individuals with acute fever and treated with antimalarials (proportion estimates & 95% confidence intervals)
Figure 1

Sources of antimalarials in the community.

Predictors of seeking care in a public healthcare facility

Having hypothesized that the point of care would be a key determinant for receiving ACT, we examined which factors led people to seek care in a public healthcare facility. The strongest determinant was proximity: compared to people living within 15 min of a public health facility, people were less likely to seek care in the public sector if their home was located between 15 minutes and 1 hour away (odds ratio 0.40; 95% confidence intervals (0.29–0.56), P < 0.001] and even less likely when travel time was over one hour away [0.21, (0.14–0.33), P < 0.001]. (Table 4) The further away people lived from a private medicines retail outlet, the more likely they were to seek care in a public healthcare facility: from [1.20, (0.83–1.75), not significant (NS)] when travel time to a private outlet was between 15 minutes and one hour to [1.57, (1.06–2.33), P < 0.05] when travel time increased to over one hour.

Table 4 Predictors of seeking care in a public healthcare facility, of receiving an antimalarial, and of receiving ACT

While people were also more likely to seek care in a public healthcare facility if they lived in non-capital regions (2.14, (1.36–3.37), P < 0.01), education and poverty did not appear to directly affect their choice of source of care. Other factors that increased the likelihood of seeking care in a public healthcare facility were the perceptions that the closest public healthcare facility usually carries the medicines needed [1.47, (1.09–1.99), P < 0.05] and that it is possible to obtain free medicines in public healthcare facilities [1.91, (1.45–2.51), P < 0.001]. Respondents who felt that they could afford medicines were less likely to visit a public facility [0.65, (0.48–0.89), P < 0.01]. Finally, the likelihood of visiting a public facility increased with the perceived severity of illness [from 1.36, (1.02–1.82), P < 0.05 for illness perceived as moderately severe to 1.46, (1.01–2.11), P < 0.05 for illness perceived as very severe].

Predictors of antimalarial and ACT use for acute fever

Seeking care in a public health facility increased the likelihood of receiving an antimalarial for a febrile episode [1.67, (1.24–2.25), P < 0.01], as did living outside of a country’s capital area [1.52, (1.00–2.30), P < 0.05]. (Table 4) In addition, the perceived severity of illness and presence of gastro-intestinal symptoms increased the odds of receiving antimalarials [1.82, (1.38–2.40), P < 0.001 and 1.40, (1.01–1.94), P < 0.05 respectively], while upper respiratory infection (URI) symptoms and other less frequent symptoms decreased the odds [0.59, (0.44–0.79), P < 0.001 and 0.61, (0.46–0.82), P < 0.001 respectively].

By far, the most significant determinant of receiving ACT was being treated in a public healthcare facility [4.64, (2.98–7.22), P < 0.001]. Respondent education beyond high school was also associated with ACT use [2.67, (1.74–4.11), P < 0.001]. The presence of associated URI symptoms decreased the odds of receiving ACT [0.68, (0.48–0.99), P < 0.05]. No other significant associations were observed between ACT treatment and the potential predictors tested in the model.


Overall, our results underscore the high prevalence of febrile episodes responsible for high health services utilization and antimalarials use in both adults and children. A third of households reported at least one recent episode of fever. Over 90% of individuals with acute fever received treatment outside the home and reported using medicines, two-third of them received antimalarials. Published reports suggest a decrease in the true prevalence of malaria in Sub-Saharan Africa at the time of the surveys, well before the dissemination of rapid diagnostic testing (RDT) [19,20]. Yet, the use of antimalarials was very high in all five surveys irrespective of geographic location, socioeconomic status or age. Our results document widespread presumptive antimalarial treatment for febrile symptoms, a practice responsible for antimalarial overuse and emergence of antimalarial resistance. They highlight the importance of restricting antimalarials to diagnosed cases of malaria with the use of RDTs, as recommended by current WHO guidelines [21].

A key finding was the poor compliance of African communities with national policies recommending ACT as first line treatment for uncomplicated episodes of malaria. When the surveys took place in 2007–2008, national ACT policies had been implemented for at least three years in four of the five countries, and yet we found that ACT was used in only 16% of the reported febrile episodes. Our results document the gap between pharmaceutical policies in place and the reality on the ground. The highest observed ACT use was in Ghana where only 32% of individuals taking antimalarials received AS-AQ, which had been first-line treatment of malaria for four years. In addition, several instances of inappropriate artemisinin monotherapy were reported in the four countries where ACT was available and the use of halofantrine was documented in the Nigeria survey despite its ban one year earlier [12].

Results from recent ACTwatch surveys suggest that the majority of children under 5 years old with acute fever are treated at home or in the private sector [22]. However, our analysis of the WHO household surveys indicates that more than half of individuals complaining of fever seek care in public healthcare facilities. This difference may be related to the different sampling methodologies. The WHO surveys seek to draw a broader picture of community treatment decisions about seeking care and obtaining medicines. They apply no restrictive criteria to the random selection of households, collecting information on all household members, all their recent symptoms, and all medicines taken and kept at home. ACTwatch surveys strictly focus on children under 5 years old, excluding households without febrile children under 5 years old. In the five surveys we analyzed, only 39% of individuals with fever were children under 5 years old. In addition, the ACTwatch instrument attempts to capture the iterative steps that caregivers go through from the first recognition of fever in a child, while the WHO survey examines medicines use during the entire episode of illness [23].

Our study indicates that half of febrile episodes were seen in public healthcare facilities. This highlights the critical role played by the public sector in treating common ailments in communities, evidence that needs to be taken into account when designing programs to strengthen healthcare systems and eradicate malaria. Moreover, health professionals in the public sector were more likely than other healthcare providers to prescribe antimalarials and ACT; seeking care in a public healthcare facility not only increased the odds or receiving an antimalarial but was the most important determinant of receiving ACT at the time of the surveys, a result concordant with other recent reports [12,24]. Of concern, children under 5 years old, who are more vulnerable to severe disease and most in need of proper antimalarial treatment, had a slightly lower likelihood of receiving ACT than adults even though their likelihood of visiting a public healthcare facility and receiving antimalarials was somewhat higher. This finding could be related to the lack of appropriate ACT pediatric formulations at the time of the surveys. It advocates for systematically evaluating the effects of antimalarial policies in the entire community, in order to identify unintended consequences that may occur in key subgroups.

Our results illustrate how much perceptions about the health system shape healthcare behaviors of households, in particular opinions about where medicines can be best accessed, where they are most affordable, and which providers are best suited to treat more severe symptoms. As expected, convenience also played a role: households were more likely to seek care in a public facility when it was close by and when they lived in less densely populated areas where public facilities often are the only available source of care. Notably, we did not find an association between living in less densely populated regions and access to ACT, despite the higher use of public health facilities in these areas. A possible explanation is that public facilities in capital regions may have had a better supply of ACT at the time of the surveys, although this cannot be determined from our data.

The strong relationship between education and ACT use is consistent with evidence that people with higher education exhibit better recall of antimalarial names [25]. The presence of associated URI symptoms may increase the likelihood of receiving antibiotics at the expenses of antimalarials, as previously reported [15], which would explain the negative association between URI symptoms and any type of antimalarial treatment.

Finally, our results indicate that national ACT policies did not discriminate against the poor at the time of the surveys when program implementation was largely confined to the public sector. This goes against early concerns about ACT not reaching the poor; however, this situation may have changed since then and evidence of inequity is emerging with the recent development of private channels for ACT access [13,26].

The standardized WHO methodology to measure access to and use of medicines in communities of low- and middle-income countries with rapid sample surveys has several limitations in design, including underrepresentation of hard to reach areas, as well as potential variance underestimation, misclassification of households in socio-economic brackets, and underestimation of self-medication [15]. In addition, the survey depends on the respondents’ identification of medicines used; about a third of antimalarials were reported as “antimalarial,” which may have resulted in an underestimation of ACT use. While the WHO surveys did not have a special focus on malaria, results are consistent with other surveys focusing on ACT coverage [27-29]. They also provide valuable information about determinants of care seeking and patterns of antimalarial use in the early years of ACT national policy implementation. Such surveys can be recommended as affordable strategies to assess the community impact of future national policy changes to eradicate malaria, such as malaria immunization campaigns [30].


Access to ACT remained limited in five African countries in the early years of national policies encouraging its use as first-line treatment for malaria. It was largely confined to public sector health facilities where many households sought more affordable care. Since households continue to use antimalarials to treat most febrile episodes, there is a critical need for expanded use of RDT to guide appropriate treatment by community providers and caregivers.


  1. 1.

    Report of a WHO Technical Consultation. Antimalarial Drug Combination Therapy. Geneva: World Health Organization; 2001. []. Accessed October 20, 2014.

    Google Scholar 

  2. 2.

    Nyarango PM, Gebremeskel T, Mebrahtu G, Mufunda J, Abdulmumini U, Ogbamariam A, et al. A steep decline of malaria morbidity and mortality trends in Eritrea between 2000 and 2004: the effect of combination of control methods. Malar J. 2006;5:33.

    Article  PubMed Central  PubMed  Google Scholar 

  3. 3.

    Bhattarai A, Ali AS, Kachur SP, Martensson A, Abbas AK, Khatib R, et al. Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. PLoS Med. 2007;4(11):e309.

    Article  PubMed Central  PubMed  Google Scholar 

  4. 4.

    Roll Back Malaria. Global strategic plan 2005–2015. [ . 2008] Accessed October 20, 2014.

  5. 5.

    Sinclair D, Zani B, Donegan S, Olliaro P, Garner P. Artemisinin-based combination therapy for treating uncomplicated malaria. Cochrane Database Syst Rev. 2009;3:CD007483.

    PubMed  Google Scholar 

  6. 6.

    Rational Pharmaceutical Management Plus Center for Pharmaceutical Management. Changing malaria treatment policy to artemisinin-based combinations; an implementation guide. Management Sciences for Health. 2005. [] Accessed October 20, 2014.

  7. 7.

    AMFm task force of the Roll Back Malaria Partnership. Affordable medicines facility - malaria (AMFm). Roll Back Malaria. 2007. [] Accessed October 20, 2014.

  8. 8.

    Abdalla SI, Malik EM, Ali KM. The burden of malaria in Sudan: incidence, mortality and disability–adjusted life–years. Malar J. 2007;6:97.

    Article  PubMed Central  PubMed  Google Scholar 

  9. 9.

    Marsh VM, Mutemi WM, Willetts A, Bayah K, Were S, Ross A, et al. Improving malaria home treatment by training drug retailers in rural Kenya. Trop Med Int Health. 2004;9(4):451–60.

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Roll Back Malaria: Monitoring and Evaluation Reference Group. Malaria Indicator Survey: basic documentation for survey design and implementation. [] Accessed October 20, 2014.

  11. 11.

    MEASURE DHS. Demographic and Health Surveys. [] Accessed October 20, 2014.

  12. 12.

    WHO. World malaria report 2011. World Health Organization. 2011. [] Accessed October 20, 2014.

  13. 13.

    Littrell M, Gatakaa H, Evance I, Poyer S, Njogu J, Solomon T, et al. Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries. Malar J. 2011;10:327.

    Article  PubMed Central  PubMed  Google Scholar 

  14. 14.

    WHO. Guidelines for the treatment of malaria, second edition. 2010. [] Accessed October 20, 2014.

  15. 15.

    Vialle-Valentin CE, Lecates RF, Zhang F, Desta AT, Ross-Degnan D. Predictors of antibiotic use in African communities: evidence from medicines household surveys in five countries. Trop Med Int Health. 2012;2:211–22.

    Article  Google Scholar 

  16. 16.

    WHO. WHO Model List of Essential Medicines, 15th Edition. 2007. [] Accessed October 20, 2014.

  17. 17.

    Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O, et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. BMJ. 2004;329(7476):1212.

    Article  PubMed Central  PubMed  Google Scholar 

  18. 18.

    Crawley J, Chu C, Mtove G, Nosten F. Malaria in children. Lancet. 2010;375(9724):1468–81.

    Article  PubMed  Google Scholar 

  19. 19.

    Cibulskis RE, Aregawi M, Williams R, Otten M, Dye C. Worldwide incidence of malaria in 2009: estimates, time trends, and a critique of methods. PLoS Med. 2011;8(12):e1001142.

    Article  PubMed Central  PubMed  Google Scholar 

  20. 20.

    O’Meara WP, Mangeni JN, Steketee R, Greenwood B. Changes in the burden of malaria in sub-Saharan Africa. Lancet Infect Dis. 2010;10(8):545–55.

    Article  PubMed  Google Scholar 

  21. 21.

    Thiam S, Thior M, Faye B, Ndiop MÃ, Diouf ML, Diouf MB, et al. Major reduction in anti-malarial drug consumption in Senegal after nation-wide introduction of malaria rapid diagnostic tests. PLoS One. 2011;6(4):e18419.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. 22.

    O’Connell KA, Gatakaa H, Poyer S, Njogu J, Evance I, Munroe E, et al. Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries. Malar J. 2011;10:326.

    Article  PubMed Central  PubMed  Google Scholar 

  23. 23.

    Buabeng KO, Duwiejua M, Dodoo AN, Matowe LK, Enlund H. Self-reported use of anti-malarial drugs and health facility management of malaria in Ghana. Malar J. 2007;6(1):85.

    Article  PubMed Central  PubMed  Google Scholar 

  24. 24.

    Dodoo ANO, Fogg C, Asiimwe A, Nartey ET, Kodua A, Tenkorang O, et al. Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy. Malar J. 2009;8:2.

    Article  PubMed Central  PubMed  Google Scholar 

  25. 25.

    Asante KP, Abokyi L, Zandoh C, Owusu R, Awini E, Sulemana A, et al. Community perceptions of malaria and malaria treatment behaviour in a rural district of Ghana: implications for artemisinin combination therapy. BMC Public Health. 2010;10:409.

    Article  PubMed Central  PubMed  Google Scholar 

  26. 26.

    Njau JD, Goodman C, Kachur SP, Palmer N, Khatib RA, Abdulla S, et al. Fever treatment and household wealth: the challenge posed for rolling out combination therapy for malaria. Trop Med Int Health. 2006;11(3):299–313.

    Article  CAS  PubMed  Google Scholar 

  27. 27.

    Watsierah CA, Jura WG, Oyugi H, Abong’o B, Ouma C. Factors determining anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya. Malar J. 2010;9:295.

    Article  PubMed Central  PubMed  Google Scholar 

  28. 28.

    Akweongo P, Agyei-Baffour P, Sudhakar M, Simwaka BN, Konate AT, Adongo PB, et al. Feasibility and acceptability of ACT for the community case management of malaria in urban settings in five African sites. Malar J. 2011;10:240.

    Article  PubMed Central  PubMed  Google Scholar 

  29. 29.

    Onyango EO, Ayodo G, Watsierah CA, Were T, Okumu W, Anyona SB, et al. Factors associated with non-adherence to Artemisinin-based Combination Therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya. BMC Infect Dis. 2012;12(1):143.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. 30.

    Asante KP, Abdulla S, Agnandji S, Lyimo J, Vekemans J, Soulanoudjingar S, et al. Safety and efficacy of the RTS, S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial. Lancet Infect Dis. 2011;11(10):741–9.

    Article  CAS  PubMed  Google Scholar 

Download references


We thank the World Health Organization (WHO) Department of Essential Medicines and Pharmaceutical Policies (EMP) in Geneva for providing the country data sets. We gratefully acknowledge WHO essential medicines advisors, country teams, and consultants who undertook surveys of medicines access and use, providing technical support for data collection and data entry. Financial support for the design and implementation of the surveys has been provided by the WHO Department of Essential Medicines and Pharmaceutical Policies (EMP) in Geneva and by the Department for International Development, U.K. through the Medicines Transparency Alliance (MeTA). The study was supported by a Faculty Grant from the Harvard Pilgrim Health Care Institute.

Author information



Corresponding author

Correspondence to Catherine E Vialle-Valentin.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

DRD and CVV drew up the project proposal. CVV was the principal investigator for the study and wrote the first draft of the manuscript. RLC assembled original data sets and constructed analytic data sets. FZ, CVV, and RLC undertook the statistical analyses. All authors contributed to the interpretation of the data and critical revision of the manuscript. All authors have read and approved the final version.

Rights and permissions

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vialle-Valentin, C.E., LeCates, R.F., Zhang, F. et al. Treatment of Febrile illness with artemisinin combination therapy: prevalence and predictors in five African household surveys. J of Pharm Policy and Pract 8, 1 (2015).

Download citation


  • Artemisinin combination therapy
  • Household surveys
  • Appropriate use of medicines
  • Africa