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Table 9 Essential medicines for children unapproved in the US, UK, and Japan without a paediatric dosage form

From: Approval status and evidence for WHO essential medicines for children in the United States, United Kingdom, and Japan: a cross-sectional study

Name ATCa Therapeutic use Adult efficacyb Paediatric efficacyb
Paromomycin A Leishmaniasis No evidence No evidence
Diphtheria antitoxin J Diphtheria Effective Effective
Amodiaquine P Malaria No evidence No evidence
Artemether P Malaria Inconclusive Inconclusive
Artesunate P Malaria Effective Effective
Artesunate + Mefloquine P Malaria Effective Effective
Artesunate + Amodiaquine P Malaria Effective Effective
Benznidazole P American trypanosomiasis Inconclusive Favours efficacy
Sodium stibogluconate P Leishmaniasis Favours efficacy No evidence
Nifurtimox P African trypanosomiasis Inconclusive No evidence
Nifurtimox P American trypanosomiasis Inconclusive No evidence
Melarsoprol P African trypanosomiasis Favours efficacy No evidence
Suramin sodium P African trypanosomiasis Favours efficacy No evidence
Eflornithine P African trypanosomiasis Effective No evidence
Triclabendazole P Infection by Paragonimus Favours efficacy Inconclusive
Levamisole P Helminth infection Inconclusive No evidence
Benzyl benzoate P Scabies No evidence No evidence
  1. aAnatomical Therapeutic Chemical (ATC) classification code: A, alimentary tract and metabolism; J, general anti-infectives for systemic use; P, antiparasitic products
  2. b Adult or paediatric efficacy: Inconclusive, evidence is inconclusive; Favours efficacy, evidence favours efficacy