Table 2 SprayX cluster themes identified by HDBSCAN algorithm
From: Advancing medical affair capabilities and insight generation through machine learning techniques
SprayX cluster themes | ||
|---|---|---|
Cluster | Themes | Potential explorations |
Cluster -1 | Not enough cases to be classified as a cluster | N/A |
Cluster 0 | Question was missing | N/A |
Cluster 1 | Question was missing | N/A |
Cluster 2 | Safety on plane | Med info-website potential, educate pharmacists |
Allowed on plane/dangerous goods | ||
Cluster 3 | Measurement of foam (Changes have been added to PM) | # Inquiry Vs Time to see if # of questions decreased (Are the PM changes sufficient) |
Amount/actuation | ||
Concern to not exceed 15gm | ||
How much to apply? | ||
Confusion on instructions | ||
Cluster 4 | How to apply to Scalp? | Add content to Med Info Website (therein forth described as “Med Info Website”) |
Drug holidays | Med Info Website | |
Re-starting SprayX | Med Info Website | |
Long term efficacy and maintenance | Med Info Website (SprayX-Data) #Inquiry vs time to see if # of questions changes following a) rep reactive handling of HCP requests for long-term/maintenance use; b) PM changes | |
Grease removal/Can't get it out"/"Washed my hair many times"/"How to remove from scalp?"/ "Recommendations are not working" | Sending a follow-up questionnaire if the "Shampoo on dry hair” or general recommendations works after reply | |
Information in the use of SprayX post-4 weeks | Med Info Website (SprayX Data) | |
Disposal of SprayX | Educate Pharmacists, Doctors, Med Info Website | |
Paul Study: SprayX vs DrugX/ SprayX and DrugY® | Med Info Website (SprayX- Data) | |
SprayX Study: SprayX vs DrugZ/ SprayX and DrugZ | Med info Website (SprayX-Data) | |
How long to leave application on? / How long does it take to absorb? | Educate Pharmacists (part of counselling) | |
Use with vitamin D | Med Info Website | |
Use in adolescence/use in children | Med Info Website | |
Confusion on instructions of "A can lasts 4 days" with their physician’s SIG | PM improvements in wording | |
Application on off-label sensitive areas ("Can it be applied on […]” (Areas where PM advises not to use) | Med Info Website | |
SprayX vs DrugA/SprayX and DrugA | Med Info Website | |
Use in pregnancy/breastfeeding | Med Info Website | |
Putting on gloves/socks/occluding area (band-aid) after application from patients/"used under occlusion" | Educate pharmacists (part of counselling) | |
Calcium levels | Med Info Website | |
SprayX vs phototherapy/ SprayX and phototherapy | Med Info Website | |
Staining fabrics | Educate pharmacists (part of counselling) | |
Removal of product. ("Do I wait for it to dry?", "Do I need to wipe off the excess?") | Educate pharmacists (part of counseling) | |
SprayX trial data | Med Info Website (SprayX Data) | |
Any concerns with the treatment of hair (colored hair/perm) | Educate pharmacists (part of counselling), Med-Info Website | |
Risks of inhalation | Educate pharmacists (part of counseling) | |
Use of moisturizer/sunscreen | Educate pharmacists (part of counseling) | |
Psoriasis of various kinds (Pustular psoriasis, plaque psoriasis, palmoplantar psoriasis, nail psoriasis) | Med Info Website | |
Does it contain "…" | Med Info Website | |
Positive feedbacks/marketing feedback | Data visualization: use of MAFUSA | |
Hyperpigmentation | Med Info Website | |
Photocarcinogenicity/sun exposure | Educate pharmacists (part of counselling) | |
Is SprayX the same as DrugB® | Med Info Website | |
Accidentally got into eyes | Educate pharmacists (part of counselling) | |
Requests for OLA slide decks | Data visualization: use of MAFUSA | |
Cluster 5 | Appearance/"why is the foam not foaming?" | Product monograph improvements in wording |
Cold feeling after application | Med Info Website | |
Product defects | Data visualization (Use of MAFUSA) | |
Application near the eyes | Med Info Website | |
What is the environmental impact of improper disposal? | Educate pharmacists, doctors, Med Info Website | |
Compassionate use | Med Info Website (instructions/forms) | |
Cluster 6 | SprayX patient cases program: use beyond 4 weeks | N/A: Very old cases |
Cluster 7 | PV case reports—off-label use | Data visualization: use of MAFUSA |