Table 1 Examples of pharmaceutical products developed in LMICs (from oldest to most recent)
From: Rising pharmaceutical innovation in the Global South: a landscape study
Product | Type of product | Main indication | Main developer | Type of developer | Country | Years |
|---|---|---|---|---|---|---|
Ultra micro analytical system (SUMA) | Diagnostics platform | Screening of several infectious diseases | Cuban Immunoassay Center | Public institute | Cuba | 1986 |
VA-MENGOC-BC® | Vaccine | Meningitis B and C | National Center for Meningococcal Vaccine Development | Public institute | Cuba | 1989 |
Ormeloxifene | Drug | Nonsteroidal oral contraceptive | Central Drug Research Institute | Public institute | India | 1991 |
Shanvac-B | Vaccine | Hepatitis B | Shantha Biotechnics | Private company | India | 1998 |
Abhayrab® | Vaccine | Rabies | Human Biologicals Institute National Dairy Development Board | Private company Public institute | India | 2001 |
Gendicine® (recombinant human p53 adenovirus) | Gene therapy | Head and neck cancer | Shenzhen SiBiono | Private company | China | 2003 |
Acheflan® | Herbal medicine | Anti- inflammatory | Aché Laboratórios Universidade Federal de Santa Catarina Unifesp Unicamp PUC-Campinas | Private company University (public) University (public) University (public) University (private) | Brazil | 2004 |
Nepidermin | Biologic drug | Diabetic foot ulcer | Cuban Center for Genetic Engineering and Biotechnology (CIBG) | Public institute | Cuba | 2006 |
Nimotuzumab | Monoclonal antibody | Cancer | Centre of Molecular Immunology | Public institute | Cuba | 2006 |
Lodenafil carbonate | Drug | Erectile dysfunction | Cristalia | Private company | Brazil | 2007 |
CIMAvax EGF | Therapeutic vaccine | Lung cancer | Center of Molecular Immunology | Public institute | Cuba | 2008 |
Panflu.1® | Vaccine | H1N1 influenza A | Sinovac Biotech | Private company | China | 2009 |
MenAfriVac | Vaccine | Meningitis A | Serum Institute of India | Private company | India | 2009 |
Risorine | Drug | Tuberculosis | Cadila Pharmaceutical Indian Institute of Integrative Medicine | Private company Public institute | India | 2009 |
Icotinib | Drug | Lung cancer | Betta Pharmaceuticals | Private company | China | 2011 |
Perchlozone | Drug | Multidrug-resistant tuberculosis (MDR-TB) | JSC Pharmasyntez | Private company | Russia | 2012 |
Saroglitazar | Drug | Type 2 diabetes mellitus and dyslipidemia | Zydus Cadila Healthcare | Private company | India | 2013 |
Nanoxel | Drug | Cancer | Dabur Pharma Ltd | Private company | India | 2013 |
ROTAVAC | Vaccine | Diarrheal disease (rotavirus) | Bharat Biotech | Private company | India | 2014 |
Bulevirtide | Drug | Hepatitis D | Hepatera | Private company | Russia | 2017 |
Elsulfavirine | Drug | HIV | Viriom | Private company | Russia | 2017 |
Levonadifloxacin/alalevonadifloxacin | Drug | Antibiotic | Wockhardt Ltd | Private company | India | 2019 |
Ravidasvir | Drug | Hepatitis C | Pharco Pharmaceuticals Ministry of Health Pharmaniaga Berhad DNDi | Private company Government Private company PDP | Egypt Malaysia Malaysia Switzerland (headquarters) | 2021 |