Table 1 Top 25 drugs ranked by expenditure, highest to lowest, in 2001 and 2020

1. Atorvastatin

1. Infliximab

1. Erythropoietin alpha

1. Pembrolizumab

2. Omeprazole

2.Adalimumab

2. Alteplase

2. Nivolumab

3. Amlodipine

3. Ustekinumab

3. Cyclosporine

3. Daratumumab

4. Paroxetine

4. Aflibercept

4.Irinotecan

4.Rituximab

5. Simvastatin

5. Apixaban

5. Clozapine

5. Trastuzumab

6. Fluticasone

6. Metformin–sitagliptin

6. Pamidronic acid

6. Pertuzumab–Trastuzumab

7. Celecoxib

7. Semaglutide

7. Paclitaxel

7. Ibrutinib

8. Ramipril

8. Ranibizumab

8. Olanzapine

8. Durvalumab

9. Rofecoxib

9. Methylphenidate

9. Ciprofloxacin

9. Bevacizumab

10. Enalapril

10. Etanercept

10. Docetaxel

10. Vaccine, Pneumococcal conjigate

11. Olanzapine

11. Rivaroxaban

11. Filgrastim

11. Palbociclib

12. Venlafaxine

12. Sofosbuvir–velpatasvir

12. Ceftriaxone

12. Haemagglutinin (non-specific)

13. Pantoprazole

13. Budesonide–formoterol

13. Enoxparin

13. Darbepoetin alfa

14. Diltiazem

14. Empaglifozin

14. Rituximab

14. Ipilimumab

15. Pravastatin

15. Lisdexamfetamine

15. Trastuzumab

15. Osimertinib

16. Nifedipine

16. Insulin glargine

16. Abciximab

16. Nusinersen

17. Lansoprazole

17. Ibrutinib

17. Goserelin

17. Vaccine: HPV Type-6,11,16,18,3

18. Lisinopril

18. Rosuvastatin

18. Sevoflurane

18. Erythropoietin alpha

19. Clarithromycin

19. Paliperidone palmitate

19. Epirubicin

19. Alteplase

20. Sertraline

20. Golimumab

20. Gemcitabine

20. Aflibercept

21. Citalopram

21. Sitagliptin

21.Rocuronium

21. Bendamustine

22. Alendronate

22. Vedolizumab

22.Risperidone

22.Vaccine: Rotavirus

23. Ranitidine

23. Fluticasone–salmeterol

23. Omeprazole

23. Abacavir–Dolutegravir: Lamivudine

24. Risperidone

24. Glecaprevir–pibrentasvi

24. Infliximab

24. Palivizumab

25. Interferon Beta 1A

25. Atorvastatin

25. Propofol

25. Factor VIII