Table 3 Summary of interacting drug pairs with a potential for clinical significance—major and contraindicated drug interactions
Interacting drug pairs | Mechanism of action | Frequency | Percentage | |
|---|---|---|---|---|
Major drug interactions | PD/PK/UNK | n = 349 | % | |
Paracetamol | Carbamazepine | PK | 50 | 14.3 |
Amlodipine | Simvastatin | PK | 43 | 12.3 |
Ferrous sulphate | Lansoprazole | PK | 33 | 9.5 |
Carbamazepine | Simvastatin | PK | 26 | 7.4 |
Allopurinol | Aspirin | PD | 24 | 6.9 |
Aspirin | Naproxen | PD | 23 | 6.6 |
Lansoprazole | Naproxen | PD | 20 | 5.7 |
Amitriptyline | Tramadol | PD | 17 | 4.9 |
Aspirin | Clopidogrel | PD | 13 | 3.7 |
Carbamazepine | Tramadol | PK | 13 | 3.7 |
Atenolol | Naproxen | PD | 12 | 3.4 |
Hydralazine | Tramadol | PD | 10 | 2.9 |
Fluconazole | Simvastatin | PK | 8 | 2.3 |
Aspirin | Warfarin | PD | 5 | 1.4 |
Contraindicated drug interactions | PD/PK/UNK | n = 8 | % | |
|---|---|---|---|---|
Amitriptyline | Potassium Chloride | PK | 1 | 12.5 |
Desmopressin | Hydrocortisone | PD | 1 | 12.5 |
Tamoxifen | Warfarin | UNK | 1 | 12.5 |
Fluconazole | Tramadol | PK | 5 | 62.5 |