|
P
|
Problem
|
455 (100)
|
|
P1
|
Treatment effectiveness
|
393 (86.4)
|
|
P1.1
|
No effect of drug treatment
|
16 (3.5)
|
|
P1.2
|
Effect of drug treatment not optimal
|
240 (52.7)
|
|
P1.3
|
Untreated symptoms or indication
|
137 (30.1)
|
|
P2
|
Treatment safety
|
42 (9.2)
|
|
P2.1
|
Adverse drug event (possibly) occurring
|
42 (9.2)
|
|
P3
|
Other
|
20 (4.4)
|
|
P3.1
|
Problem with cost-effectiveness of the treatment
|
12 (2.6)
|
|
P3.2
|
Unnecessary drug treatment
|
8 (1.8)
|
|
C
|
Cause
|
527 (100)
|
|
C1
|
Drug selection
|
170 (32.3)
|
|
C1.1
|
Inappropriate drug according to guidelines/formulary
|
12 (2.3)
|
|
C1.2
|
Inappropriate drug (within guidelines but otherwise contra-indicated)
|
4 (0.8)
|
|
C1.3
|
No indication for drug
|
8 (1.5)
|
|
C1.4
|
Inappropriate combination of drugs
|
6 (1.1)
|
|
C1.5
|
Inappropriate duplication of therapeutic group or active ingredient
|
3 (0.6)
|
|
C1.6
|
No or incomplete drug treatment in spite of existing indication
|
137 (26.0)
|
|
C2
|
Drug form
|
0 (0.0)
|
|
C3
|
Dose selection
|
80 (15.2)
|
|
C3.1
|
Drug dose too low
|
28 (5.3)
|
|
C3.2
|
Drug dose too high
|
18 (3.4)
|
|
C3.3
|
Dosage regimen not frequent enough
|
7 (1.3)
|
|
C3.4
|
Dosage regimen too frequent
|
11 (2.1)
|
|
C3.5
|
Dose timing instructions wrong, unclear or missing
|
16 (3.0)
|
|
C4
|
Treatment duration
|
15 (2.8)
|
|
C4.1
|
Duration of treatment too short
|
9 (1.7)
|
|
C4.2
|
Duration of treatment too long
|
6 (1.1)
|
|
C5
|
Dispensing
|
45 (8.5)
|
|
C5.1
|
Prescribed drug not available
|
10 (1.9)
|
|
C5.2
|
Necessary information not provided
|
35 (6.6)
|
|
C6
|
Drug use process
|
58 (11.0)
|
|
C6.1
|
Inappropriate timing of administration or dosing intervals
|
27 (5.1)
|
|
C6.2
|
Drug under-administered
|
17 (3.2)
|
|
C6.3
|
Drug over-administered
|
3 (0.6)
|
|
C6.4
|
Drug not administered at all
|
11 (2.1)
|
|
C7
|
Patient related
|
159 (30.2)
|
|
C7.1
|
Patient uses/takes less drug than prescribed or does not take the drug at all
|
25 (4.7)
|
|
C7.2
|
Patient uses/takes more drug than prescribed
|
4 (0.8)
|
|
C7.4
|
Patient uses unnecessary drug
|
3 (0.6)
|
|
C7.6
|
Patient stores drug inappropriately
|
71 (13.5)
|
|
C7.7
|
Inappropriate timing or dosing intervals
|
29 (5.5)
|
|
C7.8
|
Patient administers/uses the drug in a wrong way
|
5 (0.9)
|
|
C7.9
|
Patient unable to use drug/form as directed
|
22 (4.2)
|
|
I
|
Interventions
|
865 (100.0)
|
|
I1
|
At prescriber level
|
351 (40.6)
|
|
I1.1
|
Prescriber informed only
|
43 (5.0)
|
|
I1.2
|
Prescriber asked for information
|
22 (2.5)
|
|
I1.3
|
Intervention proposed to prescriber
|
71 (8.2)
|
|
I1.4
|
Intervention discussed with prescriber
|
215 (24.9)
|
|
I2
|
At patient level
|
204 (23.6)
|
|
I2.1
|
Patient (drug) counseling
|
161 (18.6)
|
|
I2.3
|
Patient referred to prescriber
|
32 (3.7)
|
|
I2.4
|
Spoken to family member/caregiver
|
11 (1.3)
|
|
I3
|
At drug level
|
310 (35.8)
|
|
I3.1
|
Drug change
|
25 (2.9)
|
|
I3.2
|
Dosage change
|
84 (9.7)
|
|
I3.4
|
Instructions for use change
|
43 (5.0)
|
|
I3.5
|
Drug pause or stop
|
21 (2.4)
|
|
I3.6
|
Drug start
|
137 (15.8)
|
|
A1
|
Intervention acceptance
|
690 (79.8)
|
|
A1.1
|
Intervention accepted and fully implemented
|
608 (88.1)
|
|
A1.2
|
Intervention accepted, partially implemented
|
64 (9.3)
|
|
A1.3
|
Intervention accepted but not implemented
|
18 (2.6)
|
|
A2
|
Intervention not accepted
|
175 (20.2)
|
|
A2.1
|
Intervention not accepted: not feasible
|
8 (4.6)
|
|
A2.2
|
Intervention not accepted: no agreement
|
167 (95.4)
|
|
O
|
Outcome of intervention
| |
|
O1.1
|
Problem totally solved
|
322 (70.8)
|
|
O2.1
|
Problem partially solved
|
44 (9.7)
|
|
O3.2
|
Problem not solved, lack of cooperation of prescriber
|
85 (18.7)
|
|
O3.4
|
No need or possibility to solve problem
|
4 (0.9)
|
