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Table 2 Changes in trends in monthly DID by ATC group, DCD by primary healthcare district/healthcare management area, and DCD of drugs in the Non-BZD-H group, province of Seville

From: Analysis of changes in trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs

PHD/HMA Period (month/year) MPC Lower and upper limits t p
Monthly DID
 N05BA 01/06 04/08 0.5 0.3 0.7 4.5 < 0.0001
04/08 12/15 0.1 0.1 0.2 7.0 < 0.0001
 N05CD 01/06 12/15 0.4 0.4 0.5 40.7 < 0.0001
 N05CF 01/06 02/13 0.1 0.1 0.1 4.6 < 0.0001
02/13 08/13 −6.3 −8.1 −4.4 −6.4 < 0.0001
08/13 12/15 −0.3 −0.5 −0.1 −3.2 < 0.0001
 Total 01/06 03/09 0.4 0.3 0.5 6.8 < 0.0001
03/09 12/15 0.1 0.1 0.2 7.0 < 0.0001
Monthly DCD
 D. Seville 01/06 06/11 0.2 0.2 0.3 7.8 < 0.0001
06/11 12/15 −0.2 −0.3 −0.1 −5.5 < 0.0001
 D. Aljarafe 01/06 03/12 0.2 0.2 0.3 11.3 < 0.0001
03/12 12/15 −0.1 −0.2 −0.0 −2.8 < 0.0001
 D. Seville North 01/06 09/11 0.3 0.3 0.4 13.3 < 0.0001
09/11 12/15 −0.1 −0.2 −0.1 −3.6 < 0.0001
 D. Seville South 01/06 09/11 0.3 0.2 0.3 11.3 < 0.0001
09/11 05/16b −0.2 −0.3 −0.2 −7.1 < 0.0001
 HMA Osuna 01/06 11/11 0.3 0.3 0.4 14.0 < 0.0001
11/11 12/15 −0.1 −0.2 −0.0 −2.6 < 0.0001
 Total 01/06 09/11 0.3 0.2 0.3 10.4 < 0.0001
09/11 05/16b −0.2 −0.2 −0.1 −4.9 < 0.0001
Monthly DCDs of non-benzodiazepine hypnotics (group Non-BZD-H, N05CF)
 D. Seville 01/06 01/13 0.1 0.0 0.1 3.1 < 0.0001
01/13 08/13 −8.4 −10.6 −6.1 −7.1 < 0.0001
08/13 05/16 −0.2 −0.4 −0.0 −2.3 < 0.0001
 D. Aljarafe 01/06 02/13 0.1 0.0 0.1 3.8 < 0.0001
02/13 09/13 −6.2 −8.0 −4.4 −6.7 < 0.0001
09/13 05/16 −0.3 −0.4 −0.1 −3.5 < 0.0001
 D. Seville North 01/06 01/13 0.2 0.1 0.2 8.4 < 0.0001
01/13 06/14 −1.9 −2.3 −1.4 −8.3 < 0.0001
06/14 05/16 −0.2 −0.5 0.0 −1.7 0.1
 D. Seville South 01/06 09/11 0.0 −0.0 0.1 0.9 0.4
09/11 02/13 −0.6 −1.0 −0.2 −2.7 < 0.0001
02/13 06/13 −10.7 −15.7 −5.3 −3.8 < 0.0001
06/13 08/14 −1.2 −1.8 −0.6 −3.9 < 0.0001
08/14 05/16 0.0 −0.3 0.3 0.0 1.0
 HMA Osuna 01/06 03/13 0.0 −0.0 0.1 1.0 0.3
03/13 06/13 −15.2 −24.8 −4.4 −2.7 < 0.0001
06/13 10/15 −0.7 −1.0 −0.5 −7.1 < 0.0001
10/15 05/16 2.0 0.4 3.6 2.4 < 0.0001
 Total 01/06 01/13 0.1 0.0 0.1 3.1 < 0.0001
01/13 08/13 −6.9 −8.7 −5.0 −7.0 < 0.0001
08/13 05/16 −0.4 −0.5 −0.2 −4.7 < 0.0001
Monthly percentage change is significantly different from zero at alpha = 0.05
  1. PHD: Primary health District, HMA: healthcare management areas, MPC: monthly percentage change, DID: monthly dose per inhabitant per day, DCD: Dose per medical card per day, N05BA: group BZD-A, benzodiazepine anxiolytics: N05CD, group BZD-H: benzodiazepine hypnotics, N05CF: group Non-BZD-H: non-benzodiazepine hypnotics. Period: January 2006-May 2015