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Table 2 Changes in trends in monthly DID by ATC group, DCD by primary healthcare district/healthcare management area, and DCD of drugs in the Non-BZD-H group, province of Seville

From: Analysis of changes in trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs

PHD/HMA

Period (month/year)

MPC

Lower and upper limits

t

p

Monthly DID

 N05BA

01/06

04/08

0.5

0.3

0.7

4.5

< 0.0001

04/08

12/15

0.1

0.1

0.2

7.0

< 0.0001

 N05CD

01/06

12/15

0.4

0.4

0.5

40.7

< 0.0001

 N05CF

01/06

02/13

0.1

0.1

0.1

4.6

< 0.0001

02/13

08/13

−6.3

−8.1

−4.4

−6.4

< 0.0001

08/13

12/15

−0.3

−0.5

−0.1

−3.2

< 0.0001

 Total

01/06

03/09

0.4

0.3

0.5

6.8

< 0.0001

03/09

12/15

0.1

0.1

0.2

7.0

< 0.0001

Monthly DCD

 D. Seville

01/06

06/11

0.2

0.2

0.3

7.8

< 0.0001

06/11

12/15

−0.2

−0.3

−0.1

−5.5

< 0.0001

 D. Aljarafe

01/06

03/12

0.2

0.2

0.3

11.3

< 0.0001

03/12

12/15

−0.1

−0.2

−0.0

−2.8

< 0.0001

 D. Seville North

01/06

09/11

0.3

0.3

0.4

13.3

< 0.0001

09/11

12/15

−0.1

−0.2

−0.1

−3.6

< 0.0001

 D. Seville South

01/06

09/11

0.3

0.2

0.3

11.3

< 0.0001

09/11

05/16b

−0.2

−0.3

−0.2

−7.1

< 0.0001

 HMA Osuna

01/06

11/11

0.3

0.3

0.4

14.0

< 0.0001

11/11

12/15

−0.1

−0.2

−0.0

−2.6

< 0.0001

 Total

01/06

09/11

0.3

0.2

0.3

10.4

< 0.0001

09/11

05/16b

−0.2

−0.2

−0.1

−4.9

< 0.0001

Monthly DCDs of non-benzodiazepine hypnotics (group Non-BZD-H, N05CF)

 D. Seville

01/06

01/13

0.1

0.0

0.1

3.1

< 0.0001

01/13

08/13

−8.4

−10.6

−6.1

−7.1

< 0.0001

08/13

05/16

−0.2

−0.4

−0.0

−2.3

< 0.0001

 D. Aljarafe

01/06

02/13

0.1

0.0

0.1

3.8

< 0.0001

02/13

09/13

−6.2

−8.0

−4.4

−6.7

< 0.0001

09/13

05/16

−0.3

−0.4

−0.1

−3.5

< 0.0001

 D. Seville North

01/06

01/13

0.2

0.1

0.2

8.4

< 0.0001

01/13

06/14

−1.9

−2.3

−1.4

−8.3

< 0.0001

06/14

05/16

−0.2

−0.5

0.0

−1.7

0.1

 D. Seville South

01/06

09/11

0.0

−0.0

0.1

0.9

0.4

09/11

02/13

−0.6

−1.0

−0.2

−2.7

< 0.0001

02/13

06/13

−10.7

−15.7

−5.3

−3.8

< 0.0001

06/13

08/14

−1.2

−1.8

−0.6

−3.9

< 0.0001

08/14

05/16

0.0

−0.3

0.3

0.0

1.0

 HMA Osuna

01/06

03/13

0.0

−0.0

0.1

1.0

0.3

03/13

06/13

−15.2

−24.8

−4.4

−2.7

< 0.0001

06/13

10/15

−0.7

−1.0

−0.5

−7.1

< 0.0001

10/15

05/16

2.0

0.4

3.6

2.4

< 0.0001

 Total

01/06

01/13

0.1

0.0

0.1

3.1

< 0.0001

01/13

08/13

−6.9

−8.7

−5.0

−7.0

< 0.0001

08/13

05/16

−0.4

−0.5

−0.2

−4.7

< 0.0001

Monthly percentage change is significantly different from zero at alpha = 0.05

  1. PHD: Primary health District, HMA: healthcare management areas, MPC: monthly percentage change, DID: monthly dose per inhabitant per day, DCD: Dose per medical card per day, N05BA: group BZD-A, benzodiazepine anxiolytics: N05CD, group BZD-H: benzodiazepine hypnotics, N05CF: group Non-BZD-H: non-benzodiazepine hypnotics. Period: January 2006-May 2015
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Journal of Pharmaceutical Policy and Practice

ISSN: 2052-3211

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