|Categorization||Therapeutic group||Recommended medicines||Dosage and Prescribing notes|
|First Line||Thiazide diuretic||• Hydrochlorothiazide||hydrochlorothiazide 12.5 – 25 mg once a day. Unwanted side effects include raised plasma glucose, uric acid, and cholesterol and reduced plasma potassium|
|Calcium Channel blockers||
|Nifedipine slow release 10- 40 mg once or twice a day or Amlodipine 5-10 mg once a day.|
|Second line||Angiotensin converting enzyme (ACE) inhibitors||
Enalapril 5-40 mg once a day or Lisinopril 5-40 mg once a day. Unwanted side effects are reported as a persistent cough that might occur in 10–25% of the patients, angioedema, and postural hypotension.|
An additional warning is that all ACE inhibitors can cause excessive hypotension and renal failure is also listed. In the event of a cough developing, Angiotensin Receptors Blockers (ARBs) can be substituted for ACE inhibitors.
Hyperkalaemia can develop with the concomitant administration of ACE inhibitors with potassium supplements or potassium retaining medicines and this should only be done with careful monitoring of serum potassium.
|Angiotensin receptor blockers (ARBs)||• Losartan||Losartan 25-100 mg once or twice a day.|
|Beta blockers||• Atenolol||Atenolol 50 mg once a day. Unwanted side effects include precipitation or exacerbation of asthma, heart failure, impaired glucose control, fatigue and peripheral vascular disease.|
|Prazosin 0.5 – 5 mg twice or three times a day; or Doxazosin 4- 16 mg once a day.|