Table 3 Drug groups and associated adverse reactions recorded in the patient charts
Reported Adverse reaction* | Antimicrobial agents | Anti-cancer | Cardiovascular drugs | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antifungal drugs | Anti-tuberculosis | Beta lactams | Clindamycin | Doxycycline | Fluoroquinolones | Macrolides | Oseltamivir | Sulfa antibiotics | Vancomycin | EGFR–TKIs | Nivolumab | Platinum-based antineoplastic drugs | ACE inhibitors | CCB | Clopidogrel | Diuretics | Statins | |
Skin and soft tissue reactions | ||||||||||||||||||
Acneiform dermatitis | – | – | 1 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
AGEP | 1 | – | 2 | 1 | – | – | – | – | – | 1 | – | – | – | – | – | – | – | – |
Angioedema | – | – | 3 | 1 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bullous pemphigoid | – | – | – | – | – | – | – | – | – | – | – | 1 | – | – | – | – | – | – |
Eczematous eruption | – | 3 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Edema | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 | – | – | – |
Erythema multiforme | – | – | 4 | – | – | 1 | – | 1 | 1 | – | – | – | – | – | – | – | – | – |
Exfoliative dermatitis | 1 | 4 | 1 | – | – | – | – | – | 2 | – | – | – | – | – | – | – | – | – |
Fixed drug eruption | – | – | – | – | – | – | – | – | 2 | – | – | – | – | – | – | – | – | – |
MP rash | – | 8 | 8 | – | – | 2 | – | – | 2 | 2 | – | – | – | – | 1 | – | – | – |
Mucositis | – | – | 1 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
PRIDE | – | – | – | – | – | – | – | – | – | – | 11 | – | – | – | – | – | – | – |
Pruritic and erythematous rash | – | – | 9 | 2 | – | 3 | 4 | – | – | – | – | – | – | 1 | – | – | – | – |
SDRIFE | – | – | 1 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SJS | 1 | 4 | 1 | – | – | – | – | – | 1 | – | – | – | – | – | – | – | – | – |
TEN | 1 | – | 1 | – | – | – | – | – | 1 | – | – | – | – | – | – | – | – | – |
Urticaria | – | – | 1 | 2 | – | – | 1 | – | – | – | – | – | – | – | – | – | – | – |
Systemic reactions | ||||||||||||||||||
Anaphylaxis | – | – | 1 | – | – | – | – | – | – | – | – | – | 2 | – | – | – | – | – |
DRESS | – | 4 | 1 | – | – | – | – | – | 3 | – | – | – | – | – | – | – | – | – |
Dyspnea | – | – | 2 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Hepatitis | – | 2 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
Hypertension | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nausea and vomiting | – | – | – | – | 1 | 2 | – | – | – | – | – | – | – | – | – | – | – | – |
Syncope | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 | – | – |
Thrombocytopenia | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 | – |
Total | 4 | 25 | 37 | 6 | 1 | 8 | 5 | 1 | 12 | 3 | 11 | 1 | 2 | 1 | 2 | 1 | 1 | 1 |
Reported Adverse reaction* | Drugs for pain control | Miscellaneous | Total | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Uric lowering agents | Antiepileptics | Codeine | Local anesthetics | Muscle relaxant | NSAIDs | Pregabalin | Antihistamines | Contrast media | Flupentixol plus melitracen | Food supplement | Immunosuppressants | Pseudoephedrine | ||
Skin and soft tissue reactions | ||||||||||||||
Acneiform dermatitis | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
AGEP | – | – | – | – | – | – | – | – | – | – | – | 1 | – | 6 |
Angioedema | – | – | – | – | 1 | 7 | – | – | – | – | 1 | – | – | 13 |
Bullous pemphigoid | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
Eczematous eruption | – | – | – | – | – | – | – | – | – | – | – | – | – | 3 |
Edema | – | – | – | – | – | – | 1 | – | 1 | – | – | 1 | – | 4 |
Erythema multiforme | – | – | – | – | – | – | – | – | – | – | 1 | – | – | 8 |
Exfoliative dermatitis | – | – | – | – | – | – | – | – | – | – | – | – | – | 8 |
Fixed drug eruption | – | – | – | – | – | – | – | 2 | – | – | – | – | – | 4 |
MP rash | 3 | 1 | 1 | – | – | 2 | – | 1 | – | – | – | 1 | – | 32 |
Mucositis | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
PRIDE | – | – | – | – | – | – | – | – | – | – | – | – | – | 11 |
Pruritic and erythematous rash | – | – | – | – | – | – | – | – | – | – | – | 1 | 2 | 22 |
SDRIFE | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
SJS | – | – | 2 | – | – | – | – | – | – | – | – | – | – | 9 |
TEN | – | – | – | – | – | – | – | – | – | – | – | – | – | 3 |
Urticaria | – | – | – | – | – | 4 | – | – | – | 1 | – | – | – | 9 |
Systemic reactions | ||||||||||||||
Anaphylaxis | – | – | – | – | 1 | – | – | – | – | – | – | 1 | – | 5 |
DRESS | 2 | – | 5 | – | – | 1 | – | – | – | – | – | – | – | 16 |
Dyspnea | – | – | – | – | – | – | – | – | – | – | – | – | – | 2 |
Hepatitis | – | – | – | – | – | 1 | – | – | – | – | – | – | – | 4 |
Hypertension | – | – | – | 1 | – | – | – | – | – | – | – | – | – | 1 |
Nausea and vomiting | – | – | – | – | – | 2 | – | – | – | – | – | – | – | 5 |
Syncope | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
Thrombocytopenia | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
Total | 5 | 1 | 8 | 1 | 2 | 17 | 1 | 3 | 1 | 1 | 2 | 5 | 2 | 171 |