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Table 2 “Drugs to avoid” marketed in Australia but not listed on the PBS

From: “Drugs to avoid” to improve quality use of medicines: how is Australia faring?

Therapeutic area “Drugs to avoid” marketed but not listed on PBS Reasons for avoiding
Cardiology Bezafibrate No proven efficacy in the prevention of cardiovascular events, cutaneous, haematological and renal adverse effects
  Ranolazine Gastrointestinal and neuropsychiatric disorders, palpitations, bradycardia, hypotension, QT prolongation and peripheral oedema
Endocrinology Conjugated oestrogens + bazedoxifene Risks of thrombosis and hormone-dependent cancers have not been adequately evaluated
  Tibolone Risk of cardiovascular disorders, breast cancer and ovarian cancer
Gynaecology Ulipristal Serious liver injury
Gastroenterology Droperidol Ventricular arrhythmias and sudden death
  Glyceryl trinitrate ointment No proven efficacy for chronic anal fissure, headache that can be severe
  Prucalopride Adverse effect profile is poorly documented, particularly with respect to cardiovascular disorders, depression and suicidal ideation and teratogenicity
Infections Moxifloxacin Toxic epidermal necrolysis and fulminant hepatitis and has also been linked to an increased risk of cardiac disorders
Oncology Nintedanib Indicated for non-small cell lung cancer serious adverse effects including venous thromboembolism, bleeding, hypertension, gastrointestinal perforations and impaired wound healing
  Panobinostat Many, often serious and life-threatening adverse effects
  Vandetanib Serious adverse effects (diarrhoea, pneumonia, hypertension) occur in about one-third of patients. There is also a risk of interstitial lung disease, torsades de pointes and sudden death
  Vinflunine High risk of haematological adverse effects (including aplastic anaemia), and a risk of serious infections and cardiovascular disorders (torsades de pointes, myocardial infarction, ischaemic heart disease)
Pain Etoricoxib Excess of cardiovascular events (including myocardial infarction and thrombosis) and skin reactions
  Glucosamine Allergic reactions (angioedema, acute interstitial nephritis) and hepatitis
  Parecoxib Excess of cardiovascular events (including myocardial infarction and thrombosis) and skin reactions
Psychiatry Agomelatine No proven efficacy, hepatitis and pancreatitis, suicide and aggression, as well as serious skin disorders including Stevens–Johnson syndrome
  Dapoxetine Aggressive outbursts, serotonin syndrome, and syncope
  Milnacipran Cardiac disorders (hypertension, tachycardia, arrhythmias, QT prolongation)
Respiratory medicines Bromhexine Risk of anaphylactic reactions and severe, sometimes fatal cutaneous reactions such as erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis
  Phenylephrine Serious and even life-threatening cardiovascular disorders, including hypertensive crisis, stroke and arrhythmias, as well as ischaemic colitis
Weight loss Bupropion + naltrexone Neuropsychiatric disorders (including aggressiveness, depression and suicidal ideation), potentially severe allergic reactions (including angioedema and Stevens–Johnson syndrome), addiction, and congenital heart defects in children exposed to the drug in utero