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Table 2 Proportionality analysis of number of medicines registered vs top 8 disease burdens

From: Linking market authorizations of medicines with disease burden in South Africa

TOP 8 diseases % Disease burden (a) Medicines registered with unique APIs Total medicines registered
n % (b) Correlation
(a, b)
Median registration time (months) n % (c) Correlation
(a–c)
Median registration time (months)
Cardiovascular 29 49 25 4 57 580 38 − 9 56
COPD 4 13 7 − 3 70 99 7 − 3 39
Diabetes mellitus 7 12 6 1 50 49 4 3 48
Diarrheal diseases 4 3 2 2 57 9 1 3 62
HIV/AIDS 40 51 26 14 32 233 16 24 32
Lower respiratory infections 8 39 20 − 12 60 327 22 − 14 63
Other dementias 3 18 9 − 6 67 162 11 − 7 56
Tuberculosis 6 10 5 1 39.5 17 1 5 40
  1. High levels of correlation were defined as ≤ 5% difference between the values for % disease burden (a) and % medicines registered unique API (b) or difference between the values for % disease burden (a) % total medicines registered (c). Low levels of correlation were defined as > 5% of these values