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Table 2 Proportionality analysis of number of medicines registered vs top 8 disease burdens

From: Linking market authorizations of medicines with disease burden in South Africa

TOP 8 diseases

% Disease burden (a)

Medicines registered with unique APIs

Total medicines registered

n

% (b)

Correlation

(a, b)

Median registration time (months)

n

% (c)

Correlation

(a–c)

Median registration time (months)

Cardiovascular

29

49

25

4

57

580

38

− 9

56

COPD

4

13

7

− 3

70

99

7

− 3

39

Diabetes mellitus

7

12

6

1

50

49

4

3

48

Diarrheal diseases

4

3

2

2

57

9

1

3

62

HIV/AIDS

40

51

26

14

32

233

16

24

32

Lower respiratory infections

8

39

20

− 12

60

327

22

− 14

63

Other dementias

3

18

9

− 6

67

162

11

− 7

56

Tuberculosis

6

10

5

1

39.5

17

1

5

40

  1. High levels of correlation were defined as ≤ 5% difference between the values for % disease burden (a) and % medicines registered unique API (b) or difference between the values for % disease burden (a) % total medicines registered (c). Low levels of correlation were defined as > 5% of these values