Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Adem, Fuad; Abdela, Jemal; Edessa, Dumessa; Hagos, Bisrat; Nigussie, Abraham; Mohammed, Mohammed A.

doi:10.1186/s40545-021-00312-z

Journal of Pharmaceutical Policy and Practice

Table 2 Characteristics of the included studies

Author	Year	Design	Population	Study area	Department of the hospital at which study performed	Medical condition	Sample size	Number with Event (DRPs)	Total number of event (DRPs)	Sub-types of drug therapy problems						Sub-types of DRPs
Author	Year	Design	Population	Study area	Department of the hospital at which study performed	Medical condition	Sample size	Number with Event (DRPs)	Total number of event (DRPs)	Unnecessary drug therapy	Need additional drug therapy	Ineffective drug	Low dose	High dose	Adverse drug reaction	Non-compliance
Mohammednur et al [45]	2014	Cross-sectional	Adult	Adama Referal Hospital	Ambulatory care	Hypertension	192	155	452	10			90	81	179	86
Gebre et al [34]	2017	Cross-sectional	Adult	Tikur Anbessa Specialized Hospital	Ambulatory care	Diabetes	418	177	207	20	52	54	58	5	18
Gobezie et al [46]	2014	Cross-sectional	Adult	Ambo General Hospital	Ambulatory care	Hypertension	151	118	200	37	24	19	24		15	81
Gobezie et al [24]	2013	Prospective general cohort study	Adult	Felege Hiwot Referal Hospital	Ambulatory care	Heart failure	76	73	104		57	11	6	10	20
Aster et al [26]	2019	Prospective general cohort study	Adult	Jimma University Medical Centre	Medical ward	Chronic kidney disease	103	81	200	9	62	20	36	29	4	40
Yaschilal et al [43]	2014	Prospective general cohort study	Adult	Dessie Referal Hospital	Medical ward	Mixed	147	111	159	48	57	3	21	6	15	9
Abadir et al [47]	2015	Cross-sectional	Adult	Dilchora Referal Hospital	Ambulatory care	Hypertension	271	193	318	5	182	21				124
Gashaw et al [54]	2016	Cross-sectional	Adult	Gondar University Referal Hospital	Medical ward	Mixed	256	169	174	7	42		36	32	8	25
Yirga et al [27]	2015	Prospective observational study	Adult	Jimma University Medical Centre	Ambulatory care	Heart failure	340	284	883	34	241	243	245	14	26	80
Tamene et al [28]	2014	Prospective observational study	Adult	Jimma University Medical Centre	Medical ward	Mixed	152	115	221	45	48	14	48	23	14	29
Bereket et al [29]	2014	Cross-sectional	Adult	Jimma University Medical Centre	Medical ward	Mixed	257	189	316	47	103	42	44	49		31
Mohammed et al [30]	2016	Cross-sectional	Adult	Jimma University Medical Centre	Ambulatory care	Diabetes and Hypertension	300	70	494	51	145	138	78	9	13	60
Mequanent et al [55]	2014	Cross-sectional	Paediatrics	Zewditu Referal Hospital	Paediatrics ward	Mixed	285	90	106	8	3		35	36	24
Asgedom et al [48]	2016	Cross-sectional	Adult	Ayder Referal Hospital	Ambulatory care	Hypertension	241	134	357	40	61	44	60	3	6	143
Kaleab et al [49]	2015	Cross-sectional	Adult	G/Tsadik Shawo General Hospital	Ambulatory care	Heart failure	132	86	163	10	54	17	4	11	21	46
Eskinder et al [35]	2013	Cross-sectional	Adult	Tikur Anbessa Specialized Hospital	Ambulatory care	Cancer	367	274	474	62	30	65	69	78	170
Hailu et al [50]	2015	Cross-sectional	Adult	Wolaita Referal Hospital	Ambulatory care	Diabetes	243	202	378	16	137	8	65	14	11	127
Malede et al [36]	2018	Prospective observational study	Paediatrics	Tikur Anbessa Specialized Hospital	Ambulatory care	Cancer	176	107	257	25	70	11	60	41	14	36
Beshir et al [37]	2017	Cross-sectional	Adult	Tikur Anbessa Specialized Hospital	Ambulatory care	Epilepsy	191	134	352	3	18	98	39	33	161
Elham et al [25]	2017	Cross-sectional	Adult	Tikur Anbessa Specialized Hospital	Ambulatory care	Heart failure	423	277	572	31	69	100	129	82	161
Mohammed et al [38]	2014	Cross-sectional	Adult	Tikur Anbessa Specialized Hospital	Medical ward	Mixed	225	117	152	7	17	4	11	34	59
Tadele et al [53]	2015	Prospective observational study	Adult	Mizan, Bonga & Teppi General Hospital	Medical ward	Mixed	348	233	390	58	91	45	65	46	22	63
Ayele et al [41]	2017	Cross-sectional	Adult	Madda-Walabu University Goba Referal Hospital	Ambulatory care	Diabetes	216	190	446	16	224	28	55	3	23	97
Tamene et al [42]	2017	Cross-sectional	Adult	Hiwot Fana Specialized University Hospital	Ambulatory care	Heart failure	216	131	131	16	76	9	14			16
Haymen et al [40]	2018	Cross-sectional	Adult	Hiwot Fana Specialized University Hospital	Ambulatory care	Diabetes	148	127	127	25		25	46			31
Berhane et al [31]	2017	Prospective observational study	Adult	Jimma University Medical Centre	Medical and Surgical ward	Mixed	200	161	449	81	69	181			92	26
Gobezie et al [50]	2013	General cohort study	Adult	Jimma University Medical Centre & Felege Hiwot Referal Hospital	Ambulatory care	Heart failure	97	86	179	7	106	12	5	27	22
Yohannes et al [41]	2017	Cross-sectional	Adult	Hiwot Fana Specialized University Hospital	Ambulatory care	Diabetes and hypertension	203	179	364	39	77				69	179
Bereket et al [32]	2013	Cross-sectional	Adult	Jimma University Medical Centre	Medical ward	Mixed	257	140	316	47	103	42	44	49		31
Gizachew et al [44]	2018	Prospective observational study	Paediatrics	Dessie Referal Hospital	Paediatrics ward	Mixed	81	71	119	20	30	3	22	10	10	24
Gubae et al [39]	2017	Cross-sectional	Adult	Tikur Anbessa Specialized Hospital	Ambulatory care	Schizophrenias	117	62
Gosaye et al [33]	2017	Cross-sectional	Adult	Jimma University Medical Centre	Surgical ward	Mixed	300	228	418	66	52	21	124	81	26	48

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ISSN: 2052-3211

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