Fig. 1

Clinical trial analysis according to type (a) and status (b). The current ATMP pipeline analysed retrieved clinical trials on ATMPs from the clinicaltrials.gov database and selecting with the following inclusion criteria: interventional studies, phase II/, II/III and III studies, ongoing or completed studies, 1/07/2017–1/7/2019 as temporal limitation, and Directive 2001/83/EC plus Committee for Advanced Therapies algorithm used as definition of “ATMP”. Of 249 clinical trials included in the final analysis (after exclusion of duplicates and those not targeting ATMPs), 181 (73%) were conducted on cell therapies (CAR-Ts included), 59 (24%) on gene therapies, and 9 (4%) on tissue engineering products (figure a), while 122 (49%) were actively ongoing and recruiting, 76 (31%) not yet recruiting, and 51 (20%) completed (figure b)