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Table 3 Frequency of secondary indications by disease area

From: Repurposing existing drugs for new uses: a cohort study of the frequency of FDA-granted new indication exclusivities since 1997

Disease group

Number of associated approved drugs

Number of drugs with post-approval indication

Percent with post-approval indication (%)

Neoplasms

22

12

54

Skin and connective tissue disease

19

9

48

Digestive system diseases

12

5

41

Musculoskeletal diseases

10

4

40

Endocrine system diseases

8

3

38

Respiratory tract diseases

9

3

33

Nutritional and metabolic diseases

18

6

33

Pathological conditions, signs and symptoms

7

2

29

Hemic and lymphatic disease

11

3

27

Nervous system disease

52

14

26

Infections

27

7

25

Cardiovascular disease

28

7

25

Immune system diseases

13

3

23

Female urogenital diseases and pregnancy complications

14

3

21

Chemically induced disorders

5

2

20

Male urogenital diseases

17

3

18

Stomatognathic diseases

1

0

0

Eye diseases

5

0

0

Congenital, hereditary diseases, and neonatal and abnormalities

8

0

0

Wounds and injuries

2

0

0

  1. Drugs indications are extracted from FDA database. Each indication is matched with related USA National Library of Medicine Drugs Category. Data are drugs approved by FDA after 1997