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Table 3 Frequency of secondary indications by disease area

From: Repurposing existing drugs for new uses: a cohort study of the frequency of FDA-granted new indication exclusivities since 1997

Disease group Number of associated approved drugs Number of drugs with post-approval indication Percent with post-approval indication (%)
Neoplasms 22 12 54
Skin and connective tissue disease 19 9 48
Digestive system diseases 12 5 41
Musculoskeletal diseases 10 4 40
Endocrine system diseases 8 3 38
Respiratory tract diseases 9 3 33
Nutritional and metabolic diseases 18 6 33
Pathological conditions, signs and symptoms 7 2 29
Hemic and lymphatic disease 11 3 27
Nervous system disease 52 14 26
Infections 27 7 25
Cardiovascular disease 28 7 25
Immune system diseases 13 3 23
Female urogenital diseases and pregnancy complications 14 3 21
Chemically induced disorders 5 2 20
Male urogenital diseases 17 3 18
Stomatognathic diseases 1 0 0
Eye diseases 5 0 0
Congenital, hereditary diseases, and neonatal and abnormalities 8 0 0
Wounds and injuries 2 0 0
  1. Drugs indications are extracted from FDA database. Each indication is matched with related USA National Library of Medicine Drugs Category. Data are drugs approved by FDA after 1997