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Table 2 Comparison of antibiotics use in pre-ASP and post -ASP phases

From: An antibiotic stewardship program in a surgical ICU of a resource-limited country: financial impact with improved clinical outcomes

Variable Pre-ASP intervention (n = 123) Post-ASP intervention (n = 125) p value
Total number of antibiotics doses 4400 2840 < 0.01
DDDs/1000 patient-days*
Total antibiotics used 368 175 < 0.01
Prophylactic antibiotics    
 Ceftriaxone 450 120 < 0.01
 Metronidazole 280 110 < 0.01
 Cefazolin 228 60 < 0.01
Empirical and therapeutic antibiotics    
 Carbapenems 540 420 0.23
 Piperacillin/tazobactam 390 150 < 0.01
 Vancomycin 320 190 < 0.01
 Colistin 310 240 0.24
Mean duration of antibiotics therapy (days)**
Prophylactic antibiotics    
 Ceftriaxone 5.5 (2.3) 1.8 (1.3) < 0.01
 Cefazolin 4.3 (2.7) 1.9 (1.4) < 0.01
 Metronidazole 3.0 (2.2) 1.5 (0.7) < 0.01
Empirical and therapeutic antibiotics    
 Piperacillin/tazobactam 6.7 (3.4) 2.7 (1.2) < 0.01
 Carbapenem 10 (3.6) 4.4 (2.3) < 0.01
 Vancomycin 6.5 (3.7) 3.1 (1.7) < 0.01
 Colistin 7.9 (4.6) 4.8 (2.6) < 0.01
Other clinical measures
 Length of stay in SICU (days)** 5.2 (3.1) 4.7 (3.0) 0.09
 Mortality 21 (17.1%) 18 (14.4%) 0.67
 Readmissions 3.0 (2.4%) 1.0 (0.8%) 0.07
  1. *Defined daily dose/1000 patient days; **data presented as mean (SD); SICU = surgical intensive care unit; ASP = antibiotic stewardship program