Variable | Pre-ASP intervention (n = 123) | Post-ASP intervention (n = 125) | p value |
---|---|---|---|
Total number of antibiotics doses | 4400 | 2840 | < 0.01 |
DDDs/1000Â patient-days* | |||
Total antibiotics used | 368 | 175 | < 0.01 |
Prophylactic antibiotics | Â | Â | Â |
 Ceftriaxone | 450 | 120 | < 0.01 |
 Metronidazole | 280 | 110 | < 0.01 |
 Cefazolin | 228 | 60 | < 0.01 |
Empirical and therapeutic antibiotics | Â | Â | Â |
 Carbapenems | 540 | 420 | 0.23 |
 Piperacillin/tazobactam | 390 | 150 | < 0.01 |
 Vancomycin | 320 | 190 | < 0.01 |
 Colistin | 310 | 240 | 0.24 |
Mean duration of antibiotics therapy (days)** | |||
Prophylactic antibiotics | Â | Â | Â |
 Ceftriaxone | 5.5 (2.3) | 1.8 (1.3) | < 0.01 |
 Cefazolin | 4.3 (2.7) | 1.9 (1.4) | < 0.01 |
 Metronidazole | 3.0 (2.2) | 1.5 (0.7) | < 0.01 |
Empirical and therapeutic antibiotics | Â | Â | Â |
 Piperacillin/tazobactam | 6.7 (3.4) | 2.7 (1.2) | < 0.01 |
 Carbapenem | 10 (3.6) | 4.4 (2.3) | < 0.01 |
 Vancomycin | 6.5 (3.7) | 3.1 (1.7) | < 0.01 |
 Colistin | 7.9 (4.6) | 4.8 (2.6) | < 0.01 |
Other clinical measures | |||
 Length of stay in SICU (days)** | 5.2 (3.1) | 4.7 (3.0) | 0.09 |
 Mortality | 21 (17.1%) | 18 (14.4%) | 0.67 |
 Readmissions | 3.0 (2.4%) | 1.0 (0.8%) | 0.07 |