Skip to main content

Table 2 Comparison of antibiotics use in pre-ASP and post -ASP phases

From: An antibiotic stewardship program in a surgical ICU of a resource-limited country: financial impact with improved clinical outcomes

Variable

Pre-ASP intervention (n = 123)

Post-ASP intervention (n = 125)

p value

Total number of antibiotics doses

4400

2840

< 0.01

DDDs/1000 patient-days*

Total antibiotics used

368

175

< 0.01

Prophylactic antibiotics

   

 Ceftriaxone

450

120

< 0.01

 Metronidazole

280

110

< 0.01

 Cefazolin

228

60

< 0.01

Empirical and therapeutic antibiotics

   

 Carbapenems

540

420

0.23

 Piperacillin/tazobactam

390

150

< 0.01

 Vancomycin

320

190

< 0.01

 Colistin

310

240

0.24

Mean duration of antibiotics therapy (days)**

Prophylactic antibiotics

   

 Ceftriaxone

5.5 (2.3)

1.8 (1.3)

< 0.01

 Cefazolin

4.3 (2.7)

1.9 (1.4)

< 0.01

 Metronidazole

3.0 (2.2)

1.5 (0.7)

< 0.01

Empirical and therapeutic antibiotics

   

 Piperacillin/tazobactam

6.7 (3.4)

2.7 (1.2)

< 0.01

 Carbapenem

10 (3.6)

4.4 (2.3)

< 0.01

 Vancomycin

6.5 (3.7)

3.1 (1.7)

< 0.01

 Colistin

7.9 (4.6)

4.8 (2.6)

< 0.01

Other clinical measures

 Length of stay in SICU (days)**

5.2 (3.1)

4.7 (3.0)

0.09

 Mortality

21 (17.1%)

18 (14.4%)

0.67

 Readmissions

3.0 (2.4%)

1.0 (0.8%)

0.07

  1. *Defined daily dose/1000 patient days; **data presented as mean (SD); SICU = surgical intensive care unit; ASP = antibiotic stewardship program