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Table 6 Independent risk factors for prolonged treatment duration

From: Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study

 

Treatment duration

Univariate

OR (95% CI)

Multivariate

AOR (95% CI)

≤6 months

>6

months

Sex

Male

34 (29.8)

80 (70.2)

Ref

 

Female

23 (20.4)

90 (79.6)

0.539

(0.309–0.940)

1.623

(0.658–4.002)

Age, years

≤ 45

44 (24.9)

133 (75.1)

Ref

 

>45

13 (26)

37 (74)

0.873

(0.447–1.705)

 

Area

Urban

38 (25)

114 (75)

Ref

 

Rural

19 (25.3)

56 (74.7)

2.636

(1.48–4.695)

2.358

(1.250–4.433)

Education level

Literate

34 (26.8)

93 (93.2)

Ref

 

Illiterate

23 (23)

77 (77)

0.972

(0.560–1.688)

 

Occupation

Employed

25 (27.8)

65 (72.2)

Ref

 
 

Unemployed

32 (23.4)

105 (76.6)

0.442

(0.252–0.775)

0.633

(0.176–2.282)

BCG

Yes

12 (26.1)

34 (73.9)

Ref

 

No

45 (24.9)

136 (75.1)

1.103

(0.554–2.196)

 

Marital status

Married

28 (21.9)

100 (78.1)

Ref

 

Unmarried

29 (29.3)

70 (70.7)

0.786

(0.450–1.370)

 

Smoking habit

No

44 (26.8)

120 (73.2)

Ref

 

Yes

13 (20.6)

50 (79.4)

2.648

(1.453–4.82)

2.015

(0.987–4.114)

Chewing khat a

No

20 (23.8)

64 (76.2)

Ref

 

Yes

37 (25.9)

106 (74.1)

3.253

(1.720–6.152)

2.615

(1.201–5.691)

Monthly income (rialb)

>10,000

19 (26)

54 (74)

Ref

 

≤10,000

38 (24.7)

116 (75.3)

0.421

(0.236–0.750)

0.744

(0.231–2.404)

Knowledge

Good

51 (26.4)

142 (73.6)

Ref

 

Poor

6 (17.6)

28 (82.4)

1.411

(0.669–2.975)

 

Stigma

No

31 (24.4)

96 (75.6)

Ref

 

Yes

26 (26)

74 (74)

1.232

(0.710–2.136)

 

Comorbidities

No

50 (25.4)

147 (74.6)

Ref

 

Yes

7 (23.2)

23 (76.7)

1.323

(0.602–2.910)

 

Family history of TB

No

42 (28)

108 (72)

Ref

 

Yes

15 (19.5)

62 (80.5)

0.297

(0.667–1.214)

 

Number of TB symptoms

3–4

3 (40)

7 (70)

Ref

 

≥5

54 (24.9)

163 (75.1)

2.156

(0.447–10.41)

 

History of cough

< 3 weeks

12 (30)

28 (70)

Ref

 

≥3 weeks

45 (24.1)

142 (75.9)

2.393

(1.04–5.485)

2.672

(1.053–6.782)

Radiography lesions

Unilateral

41 (28.5)

103 (71.5)

Ref

 

Bilateral

16 (19.3)

67 (80.7)

2.021

(1.149–3.553)

2.134

(1.147–3.971

Lung cavitation

No

0 (0)

50 (100)

Ref

 

Yes

57 (32.2)

120 (67.8)

1.652

(0.819–3.333)

 

BMI, kg/m2

<18.5

38 (31.7)

88 (82.2)

Ref

 

≥18.5

19 (17.8)

88 (82.2)

1.345

(0.775–2.337)

 
  1. Ref reference group, BMI body mass index, BCG Bacillus Calmette–Guerin, AOR adjusted odds ratio, CI confidence interval
  2. akhat: a shrub that grows in parts of East Africa and Yemen, b rial: one dollar is approximately equivalent to 215 rial