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Table 6 Essential medicines for children unapproved in the US, UK, and Japan with paediatric evidence

From: Approval status and evidence for WHO essential medicines for children in the United States, United Kingdom, and Japan: a cross-sectional study

Name ATCa Therapeutic use Adult efficacyb Paediatric efficacyb Dosage formc
Potassium iodide D Cutaneous sporotrichosis Favours efficacy Favours efficacy A
Doxycycline J Malaria Favours efficacy Favours efficacy A
Amikacin J Tuberculosis Favours efficacy Favours efficacy A
Rifampicin J Leprosy Favours efficacy Favours efficacy A
Capreomycin J Tuberculosis Effective Favours efficacy A
Diphtheria antitoxin J Diphtheria Effective Effective NA
Isoflurane N General anaesthesia Effective Effective A
Primaquine P Malaria Favours efficacy Favours efficacy A
Artesunate P Malaria Effective Effective NA
Artesunate + Mefloquine P Malaria Effective Effective NA
Artesunate + Amodiaquine P Malaria Effective Effective NA
Benznidazole P American trypanosomiasis Inconclusive Favours efficacy NA
Protamine sulfate V Heparin overdose Effective Favours efficacy A
  1. aAnatomical Therapeutic Chemical (ATC) classification codes: D, dermatologicals; J, general anti-infectives for systemic use; L, antineoplastic and immunomodulating agents; N, nervous system; P, antiparasitic products; V, various
  2. bAdult or paediatric efficacy: Inconclusive, evidence is inconclusive; Favours efficacy, evidence favours efficacy
  3. cDosage Form: A, available; NA, not available