Approval status and evidence for WHO essential medicines for children in the United States, United Kingdom, and Japan: a cross-sectional study

Table 6 Essential medicines for children unapproved in the US, UK, and Japan with paediatric evidence

Name	ATC^a	Therapeutic use	Adult efficacy^b	Paediatric efficacy^b	Dosage form^c
Potassium iodide	D	Cutaneous sporotrichosis	Favours efficacy	Favours efficacy	A
Doxycycline	J	Malaria	Favours efficacy	Favours efficacy	A
Amikacin	J	Tuberculosis	Favours efficacy	Favours efficacy	A
Rifampicin	J	Leprosy	Favours efficacy	Favours efficacy	A
Capreomycin	J	Tuberculosis	Effective	Favours efficacy	A
Diphtheria antitoxin	J	Diphtheria	Effective	Effective	NA
Isoflurane	N	General anaesthesia	Effective	Effective	A
Primaquine	P	Malaria	Favours efficacy	Favours efficacy	A
Artesunate	P	Malaria	Effective	Effective	NA
Artesunate + Mefloquine	P	Malaria	Effective	Effective	NA
Artesunate + Amodiaquine	P	Malaria	Effective	Effective	NA
Benznidazole	P	American trypanosomiasis	Inconclusive	Favours efficacy	NA
Protamine sulfate	V	Heparin overdose	Effective	Favours efficacy	A

^aAnatomical Therapeutic Chemical (ATC) classification codes: D, dermatologicals; J, general anti-infectives for systemic use; L, antineoplastic and immunomodulating agents; N, nervous system; P, antiparasitic products; V, various
^bAdult or paediatric efficacy: Inconclusive, evidence is inconclusive; Favours efficacy, evidence favours efficacy
^cDosage Form: A, available; NA, not available

ISSN: 2052-3211