Table 1 Namibia ART guidelines 2008, 2010, and 2014 on the Use of NVP and response to NVP-related adverse reactions
Year of Guidelines | CD4 count threshold for ART initiation | Preferred ART regimen | Response following NVP-related adverse drug reaction (skin and liver) | Recommended Second Line ART |
|---|---|---|---|---|
Pre-2008 | <200cells/mm3 | D4T/3TC/NVP | • Grade I observe, add some medicine | TDF/3TC/LPV/r |
2008 | <200cells/mm3 | AZT/3TC/NVP | TDF/3TC/LPV/r | |
2010 | ≤350cells/mm3 | TDF/3TC/NVP | • Grade II, replace NVP with EFV | TDF/3TC/AZT/LPV/r |
• Grade III or IV, replace NVP with LPV/r | ||||
2014 | ≤500cells/mm3 | TDF/FTC/EFV | Left blank – focus is placed on NVP | AZT/FTC/LPV/r |