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Table 1 Changes in the utilization (DDDs per 100 hypertensive patients per year) of antihypertensive medications among the Palestine refugee hypertensive patient population in Jordan between 2008 (pre-STG) and 2012 (post-STG)

From: Trends in the utilization of antihypertensive medications among Palestine refugees in Jordan, 2008-2012

ATC codes

Therapeutic class

Antihypertensive utilization, % of total

Change in utilization

Percent change in utilization

2008

2012

2008-2012

2008-2012

 

Total**

280.5 (100%)

275.3(100%)

−5.23

−1.86%

C02AB01

Alpha-adrenergic agonists

2.22 (0.8%)

2.55 (0.9%)

+0.33

+14.86%

C09AA02

ACE inhibitors**

178.1 (63.5%)

132.5 (48.1%)

−45.67

−25.64%

C09CA01

Angiotensin II receptor antagonists**

0 (0%)

7.7 (2.8%)

+7.71

-

C07AA05, C07AB03

Beta blockers

53.9 (19.2%)

55.4 (20.1%)

+1.43

+2.65%

C08CA05, C08DB01, C08CA01

Calcium channel blockers

23.8 (8.5%)

26.97 (9.8%)

+3.2

+13.46%

C03AA03,C03AX01, C03CA01,C03DB01

Diuretics**

22.4 (8.0%)

50.2 (18.2%)

+27.77

+123.9% (only more than 100% is significant)

  1. DDD = defined daily dose, ACE = Angiotensin-converting enzyme; Standard Treatment Guidelines (STG) for hypertension management implemented in 2009 at UNRWA primary health clinics (PHCs).
  2. **The binomial proportion 95% confidence interval excludes the null value of zero difference (P-value <0.05).