Table 2 Incidence of adverse drug reactions by persons and person months
From: Determinants of adverse reactions to first-line antitubercular medicines: a prospective cohort study
Adverse effects | Person months | Number of Persons (%) | Number of events | Incidence†| 95% CI | |
|---|---|---|---|---|---|---|
Gastrointestinal reactions | Nausea | 1925 | 60 (15.9) | 60 | 3.12 | 2.42–4.01 |
Vomiting | 1945 | 58 (15.3) | 58 | 2.98 | 2.30–3.86 | |
Anorexia | 1900 | 65 (17.2) | 65 | 3.42 | 2.68–4.36 | |
Abdominal pain | 1989 | 50 (13.2) | 50 | 2.51 | 1.91–3.32 | |
Diarrhoea | 2011 | 46 (12.2) | 46 | 2.29 | 1.71–3.05 | |
Nervous system reactions | Ataxia | 2238 | 6 (1.6) | 6 | 0.27 | 0.12–0.60 |
Numbness | 1665 | 107 (28.3) | 107 | 6.43 | 5.32–7.77 | |
Dizziness | 1807 | 82 (21.7) | 82 | 4.54 | 3.76–5.76 | |
Impaired concentration | 2258 | 2 (0.5) | 2 | 0.09 | 0.02–0.35 | |
Slurred speech | 2247 | 4 (1.1) | 4 | 0.18 | 0.07–0.50 | |
Seizure | 2264 | 1 (0.3) | 1 | 0.04 | 0.01–0.31 | |
Peripheral neuritis | 2226 | 10 (2.6) | 10 | 0.45 | 0.24–0.84 | |
Myalgia | 1832 | 76 (20.1) | 80 | 4.37 | 3.51–5.44 | |
Arthralgia | 1794 | 86 (22.8) | 90 | 5.02 | 4.08–6.17 | |
Skin reactions | Rash | 2172 | 17 (4.5) | 17 | 0.78 | 0.49–1.26 |
Pruritus | 1914 | 62 (16.4) | 64 | 3.34 | 2.62–4.27 | |
Photosensitive skin | 2258 | 2 (0.5) | 2 | 0.09 | 0.02–0.35 | |
Genitourinary reactions | Urine discolouration | 1593 | 115 (30.4) | 124 | 7.78 | 6.53–9.28 |
Oliguria | 2256 | 2 (0.5) | 2 | 0.09 | 0.02–0.35 | |
Hepatotoxic reactions | Hepatitis | 2260 | 2 (0.5) | 2 | 0.09 | 0.02–0.35 |
Jaundice | 2229 | 7 (1.9) | 7 | 0.31 | 0.15–0.66 | |
Ophthalmic reactions | Blurred vision | 2204 | 13 (3.4) | 13 | 0.59 | 0.34–1.02 |
Reduced visual acuity | 2254 | 3 (0.8) | 3 | 0.13 | 0.04–0.41 | |
Ototoxic reactions | Tinnitus | 2240 | 5 (1.3) | 5 | 0.22 | 0.09–0.54 |
Hearing problem | 2249 | 4 (1.1) | 4 | 0.18 | 0.07–0.47 | |